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Atrial natriuretic peptide

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Atrial natriuretic peptide is released by myocytes in response to atrial stretch. There are a variety of forms; the originals isolated from the brain were smaller than the forms subsequently isolated from human heart.

Actions:

  • reduction of ADH-induced water reabsorption in the collecting ducts
  • relaxation of renal arterioles
  • modulatory effects of the GFR
  • inhibition of aldosterone mediated sodium reabsorption in the distal tubule (natiuretic effect)

There is massive atrial natriuretic peptide activity in end stage renal failure and congestive cardiac failure.

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