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Diuretic resistance

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Diuretic resistance (DR) is defined as a failure to achieve therapeutically desired congestion relief despite using an appropriate diuretic dose

In heart failure patients, the prevalence of diuretic resistance (DR) is estimated as 20%-30% (1)

  • causes of diuretic resistance include poor adherence to drug therapy or dietary sodium restriction, pharmacokinetic issues, and compensatory increases in sodium reabsorption in nephron sites that are not blocked by the diuretic

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