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Anti-inflammatory and immunosuppressive effects

Authoring team

Anti-inflammatory effects include:

  • inhibit capillary dilatation
  • limit increases in vascular permeability
  • reduced production of complement components
  • reduced production of arachidonic acid metabolites by production of an inhibitor of phospholipase A2
  • decreased release of monocytes from bone marrow
  • increased release of neutrophils from bone marrow
  • reduced leukocyte migration
  • reduced phagocytic activity
  • reduced capillary proliferation
  • reduced fibroblast proliferation

The overall effect is to limit all stages of acute and chronic inflammation with reduced ability to heal and increased susceptibility to infection.

Immunosuppressive effects include:

  • decreased T-lymphocyte response
  • decreased B-lymphocyte response
  • decreased activation of macrophages
  • limited production of lymphokines e.g. IL-2

The global effect is an impairment of cellular and humoral immunity.

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