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Endomyocardial fibrosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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This is a disease of unknown aetiology that affects African children and young adults.

Pathologically, it is characterized by:

  • fibrosis of endocardium which may extend to include the inner third of the myocardium
  • inflammatory infiltration at the junction between scar and normal myocardium

Scar contraction reduces ventricular volume and results in a restrictive cardiomyopathy. The mitral and tricuspid valves may be involved.

Endomyocardial fibrosis may occur in association with eosinophilic endomyocardial disease in temperate zones.

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