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Carvedilol

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Carvedilol is a mixed beta- and alpha-1 adrenoceptor antagonist.

Carvedilol has been licensed for treatment of:

  • hypertension:
    • doses 6.25 to 25 mg twice daily

  • symptomatic heart failure:
    • in patients with stable heart failure
    • mild to moderate symptoms (NYHA II to III)
    • start on 3.125 mg twice daily for two weeks
    • double dose at 2 weekly intervals to the maximum of 25 mg twice daily (1)

Check the summary of product characteristics before prescribing this drug.

Reference:

  • Packer, M. et al. (1996). The effect of Carvedilol on morbidity and mortality in patients with chronic heart failure. New Engl. J. Med. 334, 1349-55.

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