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Lymphoedema (comparison with lipoedema)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

 

clinical feature

lipoedema

lymphoedema

Gender

almost exclusively occurs in women

occurs in women and men

Age at onset

onset around puberty

any age

Distribution

bilateral lower extremities; symmetric involvement

unilateral, or one leg affected more severely

Foot involvement

absent, negative Stemmer's sign

present, positive Stemmer's sign

Buttock involvement

present

absent

Nature of swelling

soft, minimally pitting

firm, often marked pitting

Tenderness

common with pressure

uncommon

Easy bruising of affected area

present

absent

Improvement with elevation and compression

minimal improvement with elevation and compression

minimal improvement with elevation and compression

Family history

there is frequently a family history

less common

History of cellulitis, lymphangitis, and venous disease

uncommon

frequent

Angiosarcoma risk

there is no angiosarcoma risk associated with lipoedema

yes

MRI findings

homogenous increase in subcutaneous fat with little/no fibrosis, no skin thickening

honeycomb pattern fibrosis, edema fluid, skin thickening

Reference:

  • 1) Fonder MA et al. Lipedema, a frequently unrecognized problem Journal of the American Academy of Dermatology 2007; 57 (2): S1-S3.

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