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Minocycline-induced skin and tissue pigmentation

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  • minocycline causes skin pigmentation in 4-15% of patients (1)

  • minocycline can cause grey, blue-black or brown skin pigmentation

  • skin and tissue pigmentation is most likely to occur if minocycline is used for a long duration or at high dosage

  • patients should be warned of this possible long term side effect; they should be told to stop taking the drug at the first sign of pigmentation

  • in general, the pigmentation resolves over months or years. However in some cases the pigmentation can persist

Reference:

  • Prescribers' Journal (1998), 38(1), 47-9.

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