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Pathology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Microscopic examinatio of skin biopsy specimens is important in excluding other causes of skin ulceration.

The histopathological features of pyoderma gangrenosum are non-specific, but the following are consistent with the diagnosis:

  • massive neutrophilic infiltration
  • haemorrhage
  • necrosis of the epidermis
  • abscess formation

The following features are against a diagnosis of pyoderma gangrenosum:

  • predominantly vasculitic appearance
  • granuloma formation

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