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Aetiology of primary hypothyroidism

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Primary thyroid failure may be caused by:

Common:

  • chronic autoimmune thyroiditis
  • Hashimoto's disease
  • following thyroidectomy or radioiodine treatment
  • iodine deficiency or, rarely, gross excess
  • drug-induced
  • de Quervain's thyroiditis - usually transient
  • silent thyroiditis - usually transient; may be permanent

Uncommon:

  • post-external beam irradiation to the neck
  • congenital causes
  • infiltrative disease:
    • sarcoidosis
    • systemic amyloidosis

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