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There is evidence from the HOPE study that the presence of albuminuria indicates increased risk for myocardial infarction, stroke, cardiovascular death, congestive heart failure, and all-cause mortality.
Summary results:
outcomes at median 4.5 years | with microalbuminuria | without microalbuminuriaa | adjusted RR (95% CI) |
major cardiovascular events | 23% | 14% | 1.83 (1.64-2.05) |
all-cause mortality | 18% | 9% | 2.09 (1.84-2.38) |
CHF hospital admission | 6% | 2% | 3.23 (2.54-4.10) |
Authors of the study point out that many cardiovascular risk factors are associated with microalbuminuria, including smoking, hypertension, dyslipidaemia, hyperhomocystinemia, dietary protein, and markers of acute phase response. There is a need for further research to clearly assess the independent cardiovascular risk that occurs as a result of the presence (and degree) of albuminuria.
Glomerular Filtration and microalbuminuria:
Reference:
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