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Glycosylated haemoglobin measurement

Authoring team

Glycosylated haemoglobin (Hb A1) measurement is the most widely used measure of longterm glycaemic control in diabetes.

Glycosylated haemoglobin is produced by the non-enzymatic glycosylation of haemoglobin at a rate proportional to the prevailing glucose concentration. The level of Hb A1 depends upon:

  • red cell lifespan
  • prevailing blood glucose concentration

Providing red cell lifespan is normal, Hb A1 measures mean blood glucose concentration over the preceding 60 days - i.e. half-life of red cell.

Some assays measure total glycosylated haemoglobin whilst others measure Hb A1c produced by glycosylation of the N-terminal valine of the B-chain of haemoglobin.

Notes:

DCCT- HbA1c (%)

IFCC-HbA1c (mmol/mol)

6.0

42

6.5

48

7.0

53

7.5

59

8.0

64

9.0

75


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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