Juvenile gonadotrophin deficiency may only be detected when puberty is delayed.
The differentiation of gonadotrophin deficiency from familial late puberty is difficult before the age of 16. In the familial condition there is usually a family history and some modest penile and breast development.
Refs: 1) R. Hall in Oxford Textbook of Medicine, 2nd edition, OUP, Oxford, p.10-15 2) D. Hull & D.I. Johnston in Essential Paediatrics, 3rd edition, Churchill Livingstone, Edinburgh, p.238
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