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Lactic acidosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Lactic acid is the end product of anaerobic glycolysis.

Lactate is in equilibrium with pyruvate, anaerobic conditions increasing the normal 10:1 lactate:pyruvate ratio.

The concentration of lactate in the blood is usually less than 1 mM, but rise physiologically after severe exercise to as high as 10 mM.

Lactic acidosis should be suspected in patients with a high anion gap metabolic acidosis, when uraemia and ketoacidosis have be excluded.


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