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Semaglutide and chronic kidney disease (CKD)

Authoring team

The FLOW study investigated the benefits of using semaglutide in patients with chronic kidney disease (CKD) and type 2 diabetes:

  • randomly assigned patients with type 2 diabetes and chronic kidney disease to receive subcutaneous semaglutide at a dose of 1.0 mg weekly or placebo
  • primary outcome was major kidney disease events, a composite of the onset of kidney failure (dialysis, transplantation, or an eGFR of <15 ml per minute per 1.73 m2), at least a 50% reduction in the eGFR from baseline, or death from kidney-related or cardiovascular causes
  • median follow-up was 3.4 years
  • risk of a primary-outcome event was 24% lower in the semaglutide group than in the placebo group

The study authors concluded that:

  • semaglutide reduced the risk of clinically important kidney outcomes and death from cardiovascular causes in patients with type 2 diabetes and chronic kidney disease

Reference:

  1. Perkovic V et al. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes. NEJM May 24, 2024.

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