Clinical features

Features include:

• developmental delay, with
  • variable learning difficulties
  • speech and language delay
  • gross motor delay
  • impaired fine motor activity, with poor coordination
• increased growth, which starts prenatally, and is particularly rapid in the first two or three years, stabilising after five years, and reaching normal adult height:
  • large hands and feet
  • long arms
  • macrocephaly
  • advanced bone age
  • precocious puberty
• dysmorphic facial features:
  • dolicocephaly
  • hypertelorism
  • high palate
  • prognathism
• other developmental abnormalities:
  • cardiac
  • genitourinary
  • scoliosis