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UKPDS 38 trial

Authoring team

The objective of the UKPDS-38 trial was to determine whether tight control of blood pressure prevents macrovascular and microvascular complications in patients with type 2 diabetes.

The trial randomly assigned patients to:

  • tight control of blood pressure aiming at <150/85 mmHg
  • less tight control aiming at <180/105 mmHg

The drugs used were ACE inhibitors or beta-blockers.

Reference:

  • 1) UK Prospective Diabetes Study Group (1998). Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ, 317, 703-713

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