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In the African-American Heart Failure Trial (A-HeFT), treatment with fixed-dose combined isosorbide dinitrate/hydralazine (FDC I/H) added to neurohormonal blockade in patients with advanced HF resulted in:
Hydralazine-isosorbide dinitrate therapy is recommended for African American patients with moderate to severe heart failure with reduced ejection fraction (<40%) (HFrEF) (3).
Reference:
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