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SOLVED trial

Authoring team

The SOLVED trial was a prospective, randomised, double-blind and placebo-controlled study which investigated the effect of withdrawing digoxin from patients with heart failure.

All patients were in sinus rhythm and had stable mild to moderate heart failure treated with diuretics and digoxin.

46 patients were randomised to withdrawal of digoxin and 42 continued with digoxin.

Reference:

  • 1) Uretsky BF, Young JB, Shahidi FE, Yellen LG, Harrison MC, Jolly MK. (1993) Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. PROVED Investigative Group. J Am Coll Cardiol 1993 Oct;22(4):955-62

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