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Radiation

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Ionizing radiation is directly cytotoxic to the marrow in a dose-related fashion:

  • stem cell depletion is reversible for doses of less than 4 Gy
  • doses between 4 and 10 Gy are reversible provided that there is supportive care
  • doses greater than 10 Gy cause irreversible damage to the marrow microenvironment with the irradiated areas unable to support haemopoiesis. It is commonly observed following widespread therapeutic irradiation for malignancy.

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