This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Maddrey's discriminant function (DF)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

NICE suggest the use Maddrey's discriminant function (DF) to determine treatment in people with severe acute alcohol related hepatitis (1)

  • Maddrey's discriminant function (DF) was described to predict prognosis in alcohol-related hepatitis and identify patients suitable for treatment with steroids
    • it is 4.6 x [prothrombin time - control time (seconds)] + bilirubin in mg/dl.
      • to calculate the DF using bilirubin in micromol/l divide bilirubin value by 17
  • DF of 32 or more
    • consider liver biopsy to confirm diagnosis
    • offer corticosteroid treatment

Reference:

Related pages

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.