The deerfly vector transmits the microfilaria larval form of the worm from one host to another. The adult form of Loa loa inhabits subcutaneous tissues particularly in the periorbital area and subconjunctiva.
After fertilisation, the female liberates vast numbers of microfilariae into the blood, enabling it to be passed on to the deerfly vector. Unlike Bancroftian and Malayan filariasis, larval release typically occurs during the day.
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