Alternative options for women taking continuous combined oral HRT preparation containing 2mg of oestradiol

Alternative options for women taking continuous combined oral HRT preparation containing 2mg of oestradiol

Women taking continuous combined oral HRT preparation containing 2mg of oestradiol, can consider the following:

• Elleste Duet (trade mark) Conti 2mg oestradiol + 1mg norethisterone
• Kliofem 2mg oestradiol + 1mg norethisterone acetate
• Indivina 2mg oestradiol + 5mg medroxyprogesterone acetate
• Or take oestrogen and progestogen separately:
  • Oral oestradiol 2mg plus either:
    • micronised progesterone: Utrogestan 100mg orally at night daily on continuous basis
    • Or Provera 5mg orally daily on continuous basis
    • Or Norethisterone 5mg orally daily on continuous basis (1mg would be sufficient for use in a continuous combined regimen but not available in stand-alone preparations)
      • Off license use of norethisterone in progestogen only contraceptive pills (e.g. Noriday 3 x tablets of 350 micrograms a day, will provide 1.05mg of norethisterone) may be considered as an equivalent alternative
    • Or Mirena IUS

Reference:

• British Menopause Society. HRT preparations and equivalent alternatives Information for GPs and other health professionals (Accessed 3/5/22)