This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Cancer risk if stopped HRT

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • data from the Woman's Health Initiative trial provides data as to the risks of cancer, cardiovascular disease and fractures following stopping HRT treatment
    • analysis of delayed and sustained health benefits and risks following randomized allocation to CEE (conjugated equine estrogens) plus MPA (medroxyprogesterone acetate) vs placebo adds new information to inform the optimal use of postmenopausal CEE plus MPA
    • during postintervention follow-up - mean 2.4 years of follow-up
      • the overall risk of cardiovascular events was comparable in those initially assigned to CEE plus MPA and to placebo
      • a greater risk of malignancies was observed in the CEE plus MPA compared with the placebo group
        • greater risk of malignancies occurred in the CEE plus MPA than in the placebo group
        • more breast cancers were diagnosed in women who had been randomly assigned to receive CEE plus MPA vs placebo
        • all-cause mortality was somewhat higher in the CEE plus MPA than in the placebo group (1.20% [n = 233] vs 1.06% [n = 196]; HR, 1.15; 95% CI, 0.95-1.39)
      • no differences in the risk of fractures by treatment group were seen
    • study authors state that following termination of use of CEE plus MPA of 3.5 to 8.5 years, clinical vigilance seems warranted with respect to a sustained higher risk of malignancies

Reference:


Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.