Cervical intraepithelial neoplasia is the preinvasive stage of cervical cancer. It denotes atypical changes in the transformation zone - that part of the cervix in which exposed normal columnar epithelium is gradually replaced by normal squamous epithelium through metaplasia.
Metaplasia is enhanced by vaginal acidity and is most active during adolescence and the first pregnancy. The strong association between the development of malignancy with early sexual activity, and early age of first pregnancy is thought to be due to exposure of the transformation zone to carcinogens at times when it is most active and therefore, most vulnerable.
Cervical smear result
CIN is a histological diagnosis. It is important as:
Reference:
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