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Aetiology

Authoring team

Factors associated with gestational trophoblastic neoplasia include:

  • previous molar pregnancy - increases risk 40 fold
  • age - more common among mothers less than 20 and older than 40 years (overall is more common in older women); attributed to defective fertilisation
  • racial origin - more common among Asian and Taiwanese mothers than Caucasian
  • diet - higher incidence in areas with low consumption of folic acid and beta carotene
  • immunologic - certain combinations of maternal and paternal HLA alleles, especially when similar, may be contributory factors

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