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Hepatocellular disease and hyperlipidaemia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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  • hypertriglyceridaemia is characteristic of hepatocellular disease
    • due to triglyceride rich lipoproteins with density in the VLDL and LDL range (forms a broad beta-band on electrophoresis) - probably secondary to hepatic lipase deficiency and damage to remnant removal mechanisms
  • HDL - consists mainly of small particles with decreased cholesteryl ester (secondary to a deficiency of lecithin:cholesterol acyl transferase (catalises the esterification of free cholesterol))

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