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Aplastic crises (hereditary spherocytosis)

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Three types of aplastic crisis may punctuate the course of hereditary spherocytosis:

  • haemolytic - the most common; often mild. Probably due to reticuloendothelial hyperplasia secondary to infection. Jaundice is exacerbated.

  • aplastic - infrequent; severe. Arise from viral suppression of erythropoiesis, usually due to the human parvovirus. Both jaundice and the reticulocyte count is decreased.

  • megaloblastic - infrequent. Precipitated by inadequate dietary folic acid, especially during pregnancy when requirements are increased.

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