This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Aetiology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

CML is characterised by the reciprocal translocation between chromosomes 9 and 22 resulting in the Philadelphia chromosome (Ph) (1)

Although the molecular pathogenesis of the disease is well understood the mechanism by which gene translocation occurs is unknown (1). Aetiological agents implicated in the development of CML include:

  • radiation - is suggested as a cause since one-third of Japanese atomic bomb survivors developed CML. The effect of radiation is thought to be very low (if any) (1)
  • radiotherapy - observed with increased frequency in radiologists and patients with ankylosing spondylitis who are treated with radiation (2)

Reference:

Related pages

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.