due to high counts ( >100 x 10^9 / l) of circulating blasts
symptoms include headache, convulsion, fits, focal neurology and coma
tissue deposits of leukaemic cells:
for example, causing gum hypertrophy, stomatitis
more common in the myelomonocytic and monocytic varieties of AML
CNS involvement:
especially in ALL
occurs in 25 to 50% children and 10 to 20% of adults with acute leukaemia
acute haemostatic failure:
associated with the promyelocytic (M3) variant of AML in which the cells release cytoplasmic granular content, thus activating coagulation and fibrinolytic systems
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