This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Clinical features of leukaemic cell accumulation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

These include:

  • bone and joint pain:
    • particularly in children with ALL

  • hyperleukocytosis:
    • due to high counts ( >100 x 10^9 / l) of circulating blasts
    • symptoms include headache, convulsion, fits, focal neurology and coma

  • tissue deposits of leukaemic cells:
    • for example, causing gum hypertrophy, stomatitis
    • more common in the myelomonocytic and monocytic varieties of AML

  • CNS involvement:
    • especially in ALL
    • occurs in 25 to 50% children and 10 to 20% of adults with acute leukaemia

  • acute haemostatic failure:
    • associated with the promyelocytic (M3) variant of AML in which the cells release cytoplasmic granular content, thus activating coagulation and fibrinolytic systems

  • lymphadenopathy and hepatosplenomegaly:
    • more common in ALL than in AML

Related pages

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.