Granulopoiesis is the formation of granulocytes within the bone marrow. It is controlled by a number of substances including granulocyte colony stimulating factors.
The cell differentiation is sequentially:
The band cell is an immature neutrophil that develops in the bone marrow by further lobulation of its nucleus.
The mature neutrophils, or band cells if a left shift has occurred, along with mature basophils and eosinophils, pass through the sinus endothelium in bone marrow through to blood.
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