This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Investigations

Authoring team

The following results occur in Haemophilia A and Haemophilia B:

  • activated partial thromboplastin time (APTT); prolongation depends on the severity of the factor deficiency. Prolonged APTT plus prolonged bleeding suggests von Willebrand's disease
  • factor VIII clotting assay - low levels in Haemophilia A
  • factor IX clotting assay - low levels in Haemophilia B
  • note that in severe cases of Haemophilia B whole blood coagulation time is increased (1)

Other investigations:

  • normal tests in Haemophilia A and Haemophilia B include:
    • prothrombin time (PT)
    • bleeding time
    • normal von Willebrand factor
  • Other investigations include:
    • DNA probes - genes for Factor VIII and Factor IX have been cloned and characterised.
    • pedigree analysis - may diagnose female carriers with certainty in some situations - for example all daughters of a known haemophiliac male are obligate carriers

Reference:

  1. Hoffbrand AV, Pettitt JE (1999). Essential Haematology. Blackwell Scientific Publications, Oxford.

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.