This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Laboratory findings

Authoring team

  • red cells:
    • usually anaemia
    • cell morphology is abnormal with macrocytes, microcytes or bizarre shapes
    • MCV is normal or increased

  • WBC:
    • usually normal or reduced; but raised in chronic myelomonocytic leukaemia where monocyte count may exceed 10 x 10^9 / l
    • neutropenia is common; neutrophils may be hypogranular with one or two segments (Pelger-Huet cells), or may be hypersegmented

  • platelets - normal or reduced; some may be hypogranular

  • bone marrow - hypercellular despite low counts:
    • erythroid hyperplasia is common - abnormalities include megaloblastoid changes, nuclear budding or multinucleate erythroid precursors
    • granulocyte precursors often lack cytoplasmic granules
    • dwarf megakaryocytes with unilobed nucleus are characteristic

  • 60% of patients have chromosomal abnormalities most commonly 5, 7, 20, or Y, and trisomy 8.

Related pages

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.