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Neutrophil alkaline phosphatase

Authoring team

Leukocyte alkalline phosphatase (LAP) (neutrophil alkaline phosphatase)

  • is an enzyme present in normal neutrophils, but absent (or present at very low concentrations) in malignant neutrophils (e.g. in chronic myeloid leukaemia)
    • means that if the neutrophil count is raised, and the LAP is strongly positive in these cells, then it suggests the increase in neutrophil count is from a non malignant cause

Reference range

  • 20-180 per 100 score neutrophils

Note that reference ranges may vary between laboratories

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