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Features of advanced disease

Authoring team

The criteria for advanced phase disease include:

  • increasing splenomegaly despite full doses of cytotoxic therapy
  • rapid white cell doubling
  • white count that responds poorly to cytotoxic therapy
  • anaemia or thrombocytopenia that responds poorly to cytotoxic therapy
  • thrombocytosis >1000x10^9/l
  • 10% blasts in the blood or marrow
  • 20% (blasts + promyelocytes) in the blood or marrow
  • acquisition of "non-random" chromosomal changes in addition to the Ph chromosome
  • myelofibrosis

Reference:

  • Goldman, J. (1997). ABC of clinical haematology. BMJ. 314, 657-660.

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