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Adverse reactions

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Adverse Reactions to Polio-containing vaccine

Confirmed anaphylaxis occurs extremely rarely. Data from the UK, Canada and the US point to rates of 0.65 to 3 anaphylaxis events per million doses of vaccine given (1)

severe or mild systemic or local reaction within 72 hours of receiving a preceding vaccine. Immunisation with IPV-containing vaccine should continue following a history of (1):

  • fever, irrespective of its severity
  • hypotonic-hyporesponsive episodes (HHE)
  • persistent crying or screaming for more than three hours
  • severe local reaction, irrespective of extent

A previous version of the Green Book noted (2):

  • pain, swelling or redness at the injection site are common and may occur more frequently following subsequent doses
    • a small, painless nodule may form at the injection site; this usually disappears and is of no consequence
    • incidence of local reactions is lower with tetanus vaccines combined with acellular pertussis vaccines, than with whole-cell pertussis vaccines and similar to that after DT vaccine

Reference:

  1. Immunisation Against Infectious Disease - "The Green Book".Chapter 26 Poliomyelitis (April 2019).
  2. Immunisation Against Infectious Disease - "The Green Book".Chapter 26 Poliomyelitis (August 2006).

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