The Shy-Drager Syndrome is a form of multiple system atrophy in which autonomic failure - notably sexual and bladder dysfunction, postural hypotension and loss of sweating - is associated with parkinsonism.
The pathogenesis involves a disruption of the cells in the intermediolateral cell column of the spinal cord and the sympathetic ganglia. Sometimes neural destruction is more widespread, resulting in, for example, cerebellar signs.
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