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SMILE

Authoring team

1556 patients with anterior myocardial infarction were enrolled in the trial within 24 hr of the onset of symptoms.

Double blind randomisation assigned patients to placebo or zofenopril (initially 7.5 mg, with a target of 30 mg bd). Treatment with zofenopril was continued for 6 weeks.

Short-term and long-term outcome was improved in patients who received this short dose of ACE inhibitor. The risk of mortality was reduced by 29% at one year in the zofenopril group.

Reference:

  • Ambrosioni, E. et al. (1995). The effect of the angiotensin-converting-enzyme inhibitor Zofenopril on mortality and morbidity after anterior myocardial infarction. NEJM, 322(2), 80-85.

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