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Catastrophic antiphospholipid syndrome

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Catastrophic antiphospholipid syndrome (CAPS) is a rare life-threatening cause of multi-organ failure with an acute onset (1).

  • observed in less than 1% of APS patients (2)
  • it is characterized by the development of microthrombi in multiple small vascular beds in several organ systems leading to multioragn failure e.g. - typically the brain, kidneys, lung and the skin

Important differential diagnosis include -thrombotic thrombocytopaenic purpura, haemolytic uraemic syndrome, and disseminated intravascular coagulation (2)

Combinations of treatment are typically used including anticoagulation with heparin/warfarin. In addition Immunomodulatory therapies including plasmaphaeresis, intravenous human IgG, corticosteroids and rituximab have been employed (1).

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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