Central features of acute disseminated encephalomyelitis are fever, headache, nausea and vomiting developing within days or weeks after the resolution of the preceding infection.
These are followed by features of meningism, and then, drowsiness and multifocal neurological signs and symptoms - hemisphere, brain stem, cerebellar, spinal cord, and optic nerve involvement - optic neuritis, singly or mixed. Coma may result. The peripheral nerves are seldom affected.
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