chronic bronchopulmonary infection in childhood, with progression to bronchiectasis, which may be fatal; the underlying lesion is immunosupression
lymphoid malignancy - lymphoma and T cell leukaemia - can often occur in the teens, and can also be fatal
Reference:
Furtado S et al. A review of the inherited ataxias: recent advances in genetic, clinical and neuropathologic aspects. Parkinsonism & Related Disorders; 4 (4):161-169.
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