evidence of causative Alzheimer disease genetic mutation from family history or genetic testing
all three of the following are present:
clear evidence of decline in memory and learning and at least one other cognitive domain
steadily progressive, gradual decline in cognition, without extended plateaus
no evidence of mixed etiology (i.e. absence of other neurodegenerative disorders or cerebrovascular disease, or another neurological, mental, or systemic disease or condition likely contributing to cognitive decline.
Reference:
(1) American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), American Psychiatric Association, Arlington, VA 2013.
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