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The dementia in general paralysis of the insane is progressive and similar to that found in Alzheimer's disease.
It is associated with brisk reflexes, extensor plantar responses and tremor (usually most obvious of the lips, tongue, and outstretched hands), and is characterised by failing memory and general deterioration of cognitive function. Speech that is slow and slurred is characteristic and dysphasia (expressive and receptive) may occur.
Epileptiform seizures occur in approximately 50% of patients.
Mood changes are seen in GPI, these include depression and euphoria.
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