the dried seeds of Strychnos nux-vomica L. (Loganiaceae), is bitter and warm and, according to the TCM (Traditional Chinese Medicine) theory, belongs to the liver and spleen meridians (1,2)
dry mature seeds are disc-shaped, slightly concave, and hard
SS was first recorded in the Compendium of Materia Medica in Ming Dynasty and is now collected by the Chinese pharmacopeia
SS can be used to treat rheumatoid arthritis, facial nerve paralysis, amyotrophic lateral sclerosis and Myasthenia Gravis (MG) (1,2)
the main toxic component of SS is strychnine
alkaloids have been found to be the main active ingredient in SS, which includes strychnine, brucine and other nitrogen oxides
Reference:
Fang P et al. Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification. Evid Based Complement Alternat Med. 2022 Oct 1;2022:3056802.
Tang X et al. Exploring the mechanism of Semen Strychni in treating amyotrophic lateral sclerosis based on network pharmacology. Medicine (Baltimore). 2023 Sep 8;102(36):e35101.
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