Arachidonic acid is stored in the membranes of body cells as an ester in phosphatidylcholine and phosphatidylinositol. To form secondary mediators, it must first be released by the action of two enzymes pathways:
The phospholipase pathway also has a role in production of the precursor of platelet activating factor.
Stimulation for arachidonic acid production may be:
Glucocorticoids produce their anti-inflammatory action mainly by producing a substance which inhibits phospholipase A2.
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