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Investigation

Authoring team

Diagnosis is made on the basis of:

  • high fasting plasma gastrin
  • high gastric acid secretion:
    • usually in excess of 100 mmol/h
  • diminished response to pentagastrin

localisation of tumour:

  • demonstrable pancreatic or gastrointestinal tumour - by CT or venous sampling for gastrin
  • more than 90% of gastrinomas have somatostatin receptors, and somatostatin receptor scintigraphy has been reported to be an especially sensitive method to image gastrinomas (1)
  • also, with a skilled operator, endoscopic ultrasonography (also combined with biopsy) is also a very sensitive method to detect pancreatico-duodenal tumours

Reference:

  1. de Herder WW and Lamberts SWJ. Best Practice & Research Clinical Endocrinology & Metabolism 2004; Volume 18(4): 477-495.

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