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Tumour growth and chemotherapy

Authoring team

Tumour growth can be described in terms of the multiple of functions of:

  • the cell cycle time, T
  • the growth fraction, G
  • the rate of cell loss, L i.e.: fT x fG x fL = tumour doubling time

G is proportional to tumour mass, such that larger tumours have a smaller growth fraction - Gompertzian growth. Thus small tumours grow faster

From this, problems with chemotherapy in solid tumours are as follows:

  • low growth fraction
  • poor drug penetration
  • intrinsic drug resisitance
  • develepment of drug resistance

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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