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BRAF V600E and metastatic colorectal cancer
BRAF is a serine-threonine kinase playing a key role as downstream RAS effector in the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signal transduction cascade
BRAF V600E mutation accounts for 8-10% of metastatic colorectal cancer (mCRC) patients and it is an established prognostic factor (1,2)
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