familial pancreatic cancer (FPC) includes those kindreds that contain at least two first degree relatives with pancreatic ductal adenocarcinoma
has been suggested that about 10% of pancreatic cancer has a familial basis (1)
CDKN2A gene is situated on chromosome 9p21.3 (1,2)
CDKN2A is a tumor suppressor gene that is considered a major cause of familial melanoma
germline mutations in the p16/CDKN2A gene cause the Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome, and these individuals have a 13 to 37-fold increased risk of pancreatic cancer (1)
in melanoma-prone families of European ancestry, pancreatic cancer is the second most common type of cancers associated with CDKN2A mutations (1)
risk of developing pancreatic cancer is also higher in FDRs (first degree relatives) of carriers than in FDRs of non-carriers (RR = 7.4 [95%CI: 2.3-18.7]) (3)
Reference:
Hruban RH, Canto MI, Goggins M, Schulick R, Klein AP. Update on familial pancreatic cancer. Adv Surg. 2010;44:293-311. doi:10.1016/j.yasu.2010.05.011
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