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Interferon gamma

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Interferon gamma is distinct from interferon alpha and beta. It functions not so much as an antiviral, but as a signal between T-helper lymphocytes and mononuclear phagocytes.

It is a glycoprotein produced by:

  • T-helper lymphocytes: by far the biggest source
  • NK cells
  • CD8+ cells
  • mononuclear phagocytes

T-helper lymphocytes produce interferon gamma in response to interleukin-2 or antigen stimulation.

Its in vitro effects include:

  • production of an antiviral state
  • cytostatic for tumour cells
  • activation of mononuclear phagocytes:
    • superoxide anion production
    • phagocytosis
    • MHC class II expression
    • intracellular killing
  • activation of endothelial cells
  • pyretic
  • induction of acute phase response
  • increased class I and II MHC expression in a range of cells

Clinically, it is currently used for the treatment of chronic granulomatous disease.

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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