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NICE guidance - Enzalutamide for treating hormone-sensitive metastatic prostate cancer

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Enzalutamide plus androgen deprivation therapy (ADT) is recommended, within its marketing authorisation, as an option for treating hormone-sensitive metastatic prostate cancer in adults

Notes:

  • enzalutamide (formerly known as MDV3100) is a targeted androgen-receptor inhibitor that competitively binds to the ligand-binding domain of the androgen receptor and inhibits androgen-receptor translocation to the cell nucleus, recruitment of androgen-receptor cofactors, and androgen-receptor binding to DNA
    • enzalutamide significantly decreased the risk of radiographic progression and death and delayed the initiation of chemotherapy in men with metastatic prostate cancer (2)

Reference:

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